bronchopulmonary dysplasia
Conditions
Interventions
budesonide group :1 ml (0.5 mg) inhaled budesonide every 12 hours were given until the preterm infants no longer required respiratory support.
beclomethasome group:0.8 mg (2 ml) inhaled beclomethasome every 12 hours were given until the preterm infants no longer required respiratory support.
control group:1 ml inhaled normal saline every 12 hours were given until the preterm infants no longer required respiratory support.
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 0.1 Years
Inclusion criteria
Inclusion criteria: (1) gestational age 7 days; (2) Being admitted to hospital within 24 hours after birth and being diagnosed as RDS; (3) Non-invasive respiratory support is needed, and there are the following BPD risk factors: continuous FiO2>0.3, or gestational age < 28 weeks, or patent ductus arteriosus (hsPDA) with significant hemodynamic abnormality, or anemia requiring blood transfusion, or oligohydramnios, or intrauterine growth restriction, or risk score of BPD prediction model =-1(4) Obtain informed consent from parents.
Exclusion criteria
Exclusion criteria: (1) Severe congenital malformation (trisomy 21 syndrome, congenital diaphragmatic hernia, omphalocele, etc.); (2) Severe cyanotic congenital heart disease (such as transposition of great arteries, tetralogy of Fallot, etc.); (3) Congenital malformation of respiratory system (atresia of posterior nostril, cleft palate, tracheoesophageal fistula, etc.); (4) renal failure; (5) Vital signs are extremely unstable; (6) High frequency or constant frequency mechanical ventilation is still needed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory support duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of BPD;FiO2 is reduced by more than 75% compared with the baseline;serum NTproBNP; | — |
Countries
China
Contacts
Public ContactGao Xiangyu
Xuzhou Central Hospital
Outcome results
None listed