Birth Defect
Conditions
Interventions
Group A of simple young pregnant women:N/A
Group B of non-pure young pregnant women :N/A
Group C of simple elderly pregnant women:N/A
Group D of non-pure elderly pregnant women:N/A
Sponsors
The First Affiliated Hospital of Shihezi University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Live pregnancy (menstrual week, the last menstruation; for irregular menstruation, fetal double roof diameter and femur length were used to determine the gestational week). Single spontaneous pregnancy, regular prenatal examination in our hospital. Each pregnant woman was asked about family genetic history, disease history, abnormal pregnancy history and contact history of pregnancy risk factors. Inclusion criteria for simple pregnant women: ? Pre-birth age 35 years ? singleton natural conception ? no adverse pregnancy history ? no abnormal ultrasound structure and ultrasound soft index; Inclusion criteria for advanced age with high risk factors: ? Pre-birth age of 35 ? single natural conception ? with adverse pregnancy history (such as recurrent abortion, retained abortion, etc.) ? with abnormal ultrasound structure and ultrasound soft index; Inclusion criteria for young pregnant women alone: ? Serological screening for low-risk ? pregnant women who missed the serological screening time and required non-invasive genetic testing had normal ? ultrasound findings and no history of adverse pregnancy.
Exclusion criteria
Exclusion criteria: Pregnant women exclude moderate obesity (constitution index> 40), embryo transfer pregnancy or twin, multiple pregnancy, previous chromosome abnormalities fetal induction or childbirth, accept cell therapy, tumor patients, transplant and allogeneic blood transfusion within a year, there are amniotic cavity puncture contraindications, such as pregnant women with bleeding tendency, threatened abortion, active chronic pathogen infection or fever, NIPT detection failure, NIPT, amniotic cavity puncture results or pregnancy outcome data is incomplete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serological screening;NT;NIPT plus;System ultrasound; | — |
Countries
China
Contacts
Public ContactYajuan Gu
Department of Obstetrics, the First Affiliated Hospital of Shihezi University
Outcome results
None listed