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Cross-sectional and longitudinal study of brain functional characteristics of stroke based on DTI and fMRI brain network analysis

Cross-sectional and longitudinal study of brain functional characteristics of stroke based on DTI and fMRI brain network analysis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400091342
Enrollment
Unknown
Registered
2024-10-26
Start date
2024-11-01
Completion date
Unknown
Last updated
2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

The Stroke Group:None
Healthy control group:None

Sponsors

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1.Patient with a stroke 1). Age between 30 and 85 years old (including boundary value). 2).Patients who underwent CT or MRI scan and were diagnosed with stroke during hospitalization (January 2020 to June 2024); 3). First onset of unilateral stroke, the course of disease =6 months; 4).Two fMRI and DTI examinations were completed on admission and before discharge, and the examination results were intact. 5). Patients completed 2 rehabilitation function assessments (including NIHSS scale and Bathel index) on admission and before discharge. 2.Healthy subjects 1).Age between 30 and 85 years old (including boundary value). 2).No previous history of stroke, brain tumor, brain trauma or mental illness. 3).Voluntarily participated in this study and signed the informed consent. If the subjects were unable to read the informed consent form (e.g., illiterate subjects), witnesses were required to witness the informed consent process and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. New cerebral infarction or hemorrhage during hospitalization evaluation; 2.The development of other new complications or co-morbidities during the inpatient evaluation led to a decline in functional level. 3. There are built-in metal objects in the body that cannot be removed, such as built-in steel plates, dental implants, pacemakers, etc. 4. The presence of claustrophobia and other contraindications to MRI examination. And 5. vulnerable groups, including people with mental illness, cognitive impairment, critically ill patients, and pregnant women. 6. Incomplete clinical data (for the retrospective data part).

Design outcomes

Primary

MeasureTime frame
DTI(Diffusion Tensor Imaging);fMRI(Functional magnetic resonance imaging);

Countries

China

Contacts

Public ContactZhang Lu

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

anxiaokui733@163.com+86 136 7583 6899

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026