Heart failure
Conditions
Interventions
Gold Standard:The diagnosis of HF was based on the 2021 European Society of Cardiology Guidelines. HF was defined as the presence of symptoms or signs associated with HF and evidence of cardiac dysfun
Index test:Using 16S rRNA second-generation high-throughput sequencing technology to clarify the structural characteristics of gut microbiota. Extract the genome of fecal samples and use DNA Nanodrop
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hospitalized patients with acute decompensated heart failure aged = 60 years old; 2. Heart failure was diagnosed according to the 2021 European Society of Cardiology (ESC) guidelines for the diagnosis and treatment of acute and chronic heart failure. All patients were classified within the New York Heart Association(NYHA) functional classes II to IV; 3. No history of taking antibiotics or probiotics in the past month; 4. Complete clinical data.
Exclusion criteria
Exclusion criteria: 1.Acute coronary syndrome; 2.Severe liver cirrhosis (Child–Pugh score B or C), severe sepsis, malignant tumours or stage 5 chronic kidney disease; 3.Use antibiotics or probiotics one month before specimen collection; 4.loss of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal 16s rRNA diversity sequencing;Sensitivity;Specificity;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular related readmission rate;All-cause mortality rate; | — |
Countries
China
Contacts
Public ContactChenlin Zhuang
Fujian Provincial Hospital
Outcome results
None listed