knee osteoarthritis
Conditions
Interventions
opioid-free anesthesia :Induction of anesthesia: midazolam 0.05mg/kg, esketamine 0.3-0.4mg/kg, propofol 1-2mg/kg, cisatracurium 0.15-0.2mg/kg
Anesthesia maintenance: sevoflurane 1-3%, esketamine 0.125
Opioid anesthesia:Induction of anesthesia: midazolam 0.05mg/kg, Sufentanil 0.3-0.4ug/kg, propofol 1-2mg/kg, cisatracurium 0.15-0.2mg/kg
Anesthesia maintenance: sevoflurane 1-3%, remifentanil 0.1-0.2µg
Sponsors
Panzhihua Central Hospital
Eligibility
Sex/Gender
All
Age
19 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 19-80 years old; 2. body mass index (BMI) 18-30kg/m2; 3. American Society of Anesthesiologists (ASA) grades I - III; 4. Selective TKA under general anesthesia; 5. Able to understand and willing to use VAS score to report pain.
Exclusion criteria
Exclusion criteria: 1. The patient refuses; 2. Allergic to drugs used during anesthesia; 3. Long-term use of opioids, sedatives, antidepressants, monoamine oxidase inhibitors and other drugs; 4. Infection of the whole body or puncture site; 5. Preoperative severe complications (coagulation dysfunction, severe hypertension, heart failure, severe arrhythmia, severe lung disease, severe liver and kidney insufficiency, digestive ulcer, mental or nervous system disease, cognitive dysfunction); 6. Refusing postoperative analgesia; 7. Chronic pain in the past; 8. Obstructive sleep apnea syndrome; 9. Language communication barriers; 10. Follow-up failure or withdrawal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Sufentanil consumption 48 hours after surgery (ug);Total Sufentanil consumption 48 hours after surgery (ug);PONV;Incidence of chronic wound pain at 1 month, 3 months and 6 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate before anesthesia induction (T0), intubation time (T1), incision time (T2), after surgery time (T3), extubation time (T4);The mean arterial pressure changes before anesthesia induction (T0), at intubation time (T1), at incision time (T2), at the end of surgery (T3), at extubation time (T4) and at extubation time (T4);Rest and Exercise Visual Analog Pain Scale Score (VAS) rating;Ramsay Sedation Scale (RSS); Patient Satisfaction Score;First time of getting out of bed activity; Postoperative complications (postoperative delirium, hypoxemia, hypotension, bradycardia, respiratory depression, itching, etc.).; Length of hospital stay (defined as the time from the end of surgery to discharge); | — |
Countries
China
Contacts
Public ContactMu sihai
Panzhihua Central Hospital
Outcome results
None listed