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Acute Stroke With Large Vessel Occlusion Beyond 24 hour Time Window: A Multi-center, Prospective, Chinese Cohort of Mechanical Thrombectomy in Acute Stroke

Acute Stroke With Large Vessel Occlusion Beyond 24 hour Time Window: A Multi-center, Prospective, Chinese Cohort of Endovascular Treatment in Acute Stroke - Endovascular Treatment in Large Vessel Occlusion Beyond 24 hour Time Window

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400091326
Enrollment
Unknown
Registered
2024-10-25
Start date
2024-11-01
Completion date
Unknown
Last updated
2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke

Interventions

Endovaascular Treatment Group plus Standard Medical Therapy :NA
Standard Medical Therapy Group:NA

Sponsors

The Second Affiliated Hospital of the Army Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age =18 years; 2. Present more than 24 hours of stroke onset or last seen well; 3. Clinical diagnosis of AIS due to anterior/posterior circulation large vessel occlusion (common carotid artery; internal carotid artery (ICA); middle cerebral artery (MCA) M1 and M2 segment; vertebral artery (VA) V1-V4 segment; basilar artery) on DSA/CTA/MRA; 4. National Institute of Health stroke scale (NIHSS) =3; 5. Informed consent obtained from patients or their legal representatives.

Exclusion criteria

Exclusion criteria: 1. Intracranial hemorrhage (ICH), including parenchymal hemorrhage, ventricular hemorrhage, subarachnoid hemorrhage, and subdural/exsanguination confirmed by CT/MRI; 2. Prior modified Rankins scale (mRS)=2; 3.Pregnant or lactating women; 4. Known hereditary or acquired hemorrhagic diathesis, coagulation factor deficiency; recent oral anticoagulant therapy with International normalized ratio (INR) >3; 5. Evidence of intracranial tumor with mass effect (except small meningioma); 6. Life expectancy less than 6 months due to any advanced disease; 7. Unlikely to participate in follow-up assessments; 8. Brain herniation with midline shift; 9. Serious complications that may affect the patient's prognosis and follow-up (cancer, severe heart failure, kidney failure); 10. Presumed septic embolus, suspicion of bacterial endocarditis.

Design outcomes

Primary

MeasureTime frame
Global Outcome Score;—

Secondary

MeasureTime frame
Functional Independence outcomes;favorable outcomes;excellent outcomes;Health-related Quality of Life outcomes;NIHSS score change at 7 day;Stroke recurrence ;Global Outcome Score;symptomatic intracranial hemorrhage;any type of intracranial hemorrhage;death;—

Countries

China

Contacts

Public ContactZi Wenjie

The Second Affiliated Hospital of the Army Medical University

ziwenjie1981@163.com+86 185 2303 3816

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026