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Study on the pathogenesis involving uterine microbiome of hypertensive disorders of pregnancy

Study on the pathogenesis involving uterine microbiome of hypertensive disorders of pregnancy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400091325
Enrollment
Unknown
Registered
2024-10-25
Start date
2023-12-08
Completion date
Unknown
Last updated
2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertensive disorders of pregnancy

Interventions

Case Group:None
Control group:None

Sponsors

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Criteria for inclusion of case groups: Included patients with a diagnosis consistent with preeclampsia: Systolic blood pressure =140mmHg and/or diastolic blood pressure =90mmHg after 20 weeks of gestation, accompanied by urinary protein = 0, 3 g/24h, or random urinary protein (+), or without proteinuria, but with any of the following: (1) Thrombocytopenia (platelet < 100×109/L); (2) Liver function damage (serum transaminase level is more than 2 times the normal value); (3) Renal function impairment (creatinine level greater than 1.1mg/dl or more than 2 times the normal value); (4) Pulmonary edema; (5) New abnormalities of the central nervous system or visual disturbances; (6) signed the informed consent. Criteria for inclusion of normal pregnancy controls: (1) no complications or complications; (2) Patients who delivered cesarean section in Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; (3) signed informed consent.

Exclusion criteria

Exclusion criteria: The exclusion criteria for included patients were: (1) Hypertension during pregnancy, chronic hypertension during pregnancy, chronic hypertension complicated with preeclampsia and other hypertensive diseases during pregnancy other than preeclampsia. (2) Those who are unable or unwilling to sign informed consent, or the researcher considers that inclusion of the researcher is not appropriate for other reasons. The exclusion criteria for normal pregnancy controls were: (1) To exclude all complications and complications of pregnancy, especially placenta derived diseases such as placenta previa, fetal growth restriction, pregnancy with oligohydramnios, etc. (2) Those who are unable or unwilling to sign informed consent, or the researcher considers that inclusion of the researcher is not appropriate for other reasons.

Design outcomes

Primary

MeasureTime frame
Blood pressure;

Secondary

MeasureTime frame
Urinary protein;

Countries

China

Contacts

Public ContactFeng Ling

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

fltj007@163.com+86 138 7140 2429

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026