Postoperative cognitive dysfunction
Conditions
Interventions
Remimazolam group:Remimazolam group (R group), anesthesia induction and maintenance were treated with remimazolam. Additional medications include sufentanil, etomidate, and vecuronium.
Propofol group:Propofol group (P group), anesthesia induction and maintenance were treated with propofol. Additional medications include sufentanil, etomidate, and vecuronium.
Sponsors
The First People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Age= 65 years old and 2 hours.
Exclusion criteria
Exclusion criteria: (1) Have a history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or well-diagnosed depression before surgery; (2) Inability to communicate normally due to coma, severe dementia, speech disorder, mental disorder or serious illness; (3) Critical illness (preoperative ASA physical condition classification > grade 3), severe liver dysfunction (Child-C grade) or severe renal dysfunction (preoperative dialysis); (4) Have a history of neurosurgery; (5) History of psychotropic drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium incidence rate; | — |
Countries
China
Contacts
Public ContactKeyao Zhang
The First People's Hospital of Lianyungang
Outcome results
None listed