Study on the intervention effect of flaxseed powder on non-alcoholic fatty liver

Study on the ameliorative effect and mechanism of flaxseed power on non-alcoholic fatty liver disease through intestinal-hepatic-bile acid metabolic pathway - Study on the Intervention Effect of Flaxseed Powder on Non-alcoholic Fatty Liver Disease Population

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400091299

Enrollment

Unknown

Registered

2024-10-24

Start date

2022-10-15

Completion date

Unknown

Last updated

2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease

Interventions

intervention group:Flaxseed powder 30g/day

control group:fill in the blanks

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Adults aged 18 - 65 years; (2) Patients with mild (5% - 10% intrahepatic fat content) and moderate (10% - 25% intrahepatic fat content) NAFLD; (3) No change in medication regimen used in the past month; (4) No cancer or history of cancer; (5) Women not in pregnancy, breastfeeding, or perimenopause.

Exclusion criteria

Exclusion criteria: (1) Patients with severe NAFLD (>25% intrahepatic fat content); (2) Patients with diabetes and digestive diseases; (3) Vegetarians, weight-loss dieters (4) People with organ transplantation and organ failure; (5) People with viral hepatitis, drug-induced liver disease and other specific diseases that can lead to fatty liver; (6) Excessive alcohol consumption (>70g per week for women and >140g per week for men); (7) Those who consumed Omega-3 fatty acid supplements during the intervention; (8) Those with MRI contraindications.

Design outcomes

Primary

Measure	Time frame
magnetic resonance imaging (MRI) of the liver;Percentage of fat;	—

Secondary

Measure	Time frame
blood glucose;total cholesterol;triglyceride;HDL-C;LDL-C;insulin;ALT;AST;TNF-a;IL-6;bile acid profile;Diversity analysis of intestinal flora;	—

Countries

China

Contacts

Public ContactQiaosheng Hu

Lianshui People's Hospital Affiliated to Kanda College, Nanjing Medical University

fox1921@163.com+86 158 5177 2121

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026