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The Effect of Esketamine on Postoperative Anxiety in Women Undergoing In Vitro Fertilization-Embryo Transfer: A Double-Blind, Randomized Controlled Trial

The Effect of Esketamine on Postoperative Anxiety in Women Undergoing In Vitro Fertilization-Embryo Transfer: A Double-Blind, Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400091298
Enrollment
Unknown
Registered
2024-10-24
Start date
2024-12-02
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety

Interventions

S group: 0.3mg/kg of Esketamine + 1.5-2mg/kg of propofol
C group:1ug/kg of fentanyl and 1.5-2mg/kg of propofol

Sponsors

Sichuan Academy of Medical Sciences (Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China)
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Women aged 20-35; 2. With normal ovarian reserve; 3. Participating in a regular luteal phase protocol; 4. Undergoing their initial in vitro fertilization cycle;

Exclusion criteria

Exclusion criteria: 1. High blood pressure, diabetes, coronary heart disease, or other major illnesses; 2. Serious psychological trauma experienced by the patient within the past two years; 3. Psychotherapy; 4. Sleep disorders; 5. History of alcohol abuse or drug abuse; 6. Other reasons for discontinuation.

Design outcomes

Primary

MeasureTime frame
The incidence of anxiety after oocyte retrieval operation on day 3 (T2);

Secondary

MeasureTime frame
The incidence of anxiety 30 minutes before the retrieval of oocytes (T1);The incidence of anxiety after oocyte retrieval operation on day 15 (T3);Propofol consumption;The number of oocyte;The duration of surgery;The duration of Anesthesia;Adverse events (intraoperative hypotension, bradycardia, pain, nausea, vomiting, hallucinations);

Countries

China

Contacts

Public ContactXu Guangmin

Sichuan Academy of Medical Sciences (Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China)

xgmin2004@163.com+86 158 8240 3236

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026