Breast cancer
Conditions
Interventions
Group C:using conventional opioid anesthesia
Group OF:using opioid-free opioid anesthesia
Group NC:using conventional opioid anesthesia in patients after neoadjuvant chemotherapy
Group NOF:using opioid-free opioid anesthesia in patients after neoadjuvant chemotherapy
Sponsors
The Second Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective unilateral modified radical mastectomy for breast cancer; 2. Age between 20 and 65 years; 3. Body Mass Index (BMI) between 18 and 30 kg/m^2; 4. American Society of Anesthesiologists (ASA) classification I-II; 5. Willing to participate in this study and signed informed consent."
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative acute or chronic pain; 2. Patients with severe diseases of major organs such as the heart, brain, lungs, liver, or kidneys; 3. Patients allergic to drugs used in the study, including esketamine, dexmedetomidine, lidocaine, or ropivacaine; 4. Patients with severe bradycardia (preoperative heart rate < 50 bpm) or with cardiac conduction or rhythm abnormalities; 5. Patients with coagulation disorders or moderate to severe anemia (hemoglobin < 90 g/L); 6. Pregnant or breastfeeding women, patients with motion sickness; 7. Patients on long-term sedative or analgesic medication, chronic alcohol abusers, or drug abusers; 8. Patients with contraindications to nerve block; 9. Patients with a history of psychiatric disorders, communication difficulties, hearing impairment, or inability to understand the trial content; 10. Patients who have received glucocorticoid therapy within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The levels cortisol and adrenocorticotropic hormone ;The levels of T lymphocyte subsets (CD3+, CD4+, CD8+) and NK cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| hemodynamics ;Postoperative pain VAS score;Postoperative adverse reactions (nausea, vomiting, delirium); | — |
Countries
China
Contacts
Public ContactChuiyu Li; Zhiyuan Chen
The Second Affiliated Hospital of Fujian Medical University
Outcome results
None listed