Graves' disease
Conditions
Interventions
Graves' disease group:Subtotal thyroidectomy
11/10000 Real time Translation for Surgery for Subtotal Cardiology
Surgery for subtotal thyroidectomy
Control group of thyroid papillary microcarcinoma :Lobectomy and isthmus resection on the affected side of thyroid cancer
Sponsors
The Seventh Affiliated Hospital of Sun Yat sen University (Shenzhen)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) Case group: Diagnosed with GD, disease duration = 3 months, normal/near normal control of thyroid function. Simultaneously meet one of the following conditions: ? Accompanied by a single high-risk nodule with a diameter of less than 1.0cm; ? Thyroid II-III degree enlargement with compression symptoms or severe impact on appearance; ? Moderate to severe hyperthyroidism with poor therapeutic effect; ? Serious adverse reactions or inability to persist in taking ATD medication; ? Posterior sternal goiter; ?Patients with severe Graves orbital disease require rapid reduction of TRAb. (2) Control group: ? Age and sex can be matched with case group; ? Thyroid papillary carcinoma, single lesion; ? No Hashimoto's thyroiditis or other autoimmune diseases.
Exclusion criteria
Exclusion criteria: (1) Patients with severe heart, liver, and kidney diseases who cannot tolerate surgery; (2) Pregnant women; (3) Not signing the informed consent form and not being able to follow up after 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single cell transcriptomics and immunohistochemistry detection of thyroid tissue;Peripheral blood single-cell transcriptomics+immunohistochemistry detection; | — |
Countries
China
Contacts
Public ContactYun Peng
The Seventh Affiliated Hospital of Sun Yat sen University (Shenzhen)
Outcome results
None listed