Fracture of lower limb
Conditions
Interventions
experimental group:1. General anesthesia program: anesthesia induction program is as follows: oxycodone 0.15mg/kg, etomidate 0.3mg/kg, rocuronium bromide 0.8mg/kg, adequate oxygen denitrification afte
if the patients heart rate or blood pressure increases more than 30% of the basal value, oxycodone 0.04mg/kg is injected intravenously, and if the patients blood pressure and heart rate decreases more
control group:In the control group, sufentanil 0.4 µ g /
Sponsors
The Affiliated Yongchuan Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients (age =18 years) with lower extremity fractures requiring surgical treatment, ASA classification I-III.
Exclusion criteria
Exclusion criteria: 1) patients who refuse to participate in the trial; 2) patients allergic to the trial drug or with previous serious adverse reactions; 3) patients with long preoperative sedative or analgesic drugs; 4) patients with previous schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or severe dementia; 5) patients unable to communicate due to hearing, visual or language impairment; 6) patients with severe liver dysfunction (Child-Pugh grade C); 7) patients with severe renal dysfunction (requiring renal replacement therapy); 8) patients with traumatic shock.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative analgesic application of sufentanil or oxycodone in patients undergoing lower extremity fracture surgery on NRS scores at rest at the 3rd, 12th, 24th, and 48th postoperative hours; effects on the incidence of moderate to severe pain (NRS 4) in resting state within 48h ;Incidence of moderate-to-severe pain (NRS=4) in lower extremity activities within 48h after patients fully recovered from anesthesia;Changes in serum cortisol hormone levels and catecholamine epinephrine levels were measured before, during, and within 48h after surgery.5) The number of additional postoperative pressure presses on the analgesic pump and the number of nerve blocks performed;Incidence of postoperative complications such as nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time from the end of surgery to the first start of functional exercise;The incidence of deep vein thrombosis in the lower limbs;Postoperative hospital stay; | — |
Countries
China
Contacts
Public Contactlvzhiquan
The Affiliated Yongchuan Hospital of Chongqing Medical University
Outcome results
None listed