depressive disorder
Conditions
Interventions
depression group:Scale assessment and blood samples
control group:Scale assessment and blood samples
Sponsors
Hangzhou Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Meet the International Classification of Diseases ICD-10 criteria for the diagnosis of depressive disorders; (2) Outpatients or inpatients, aged 18-60 years; (3) Have been treated with antidepressant medication only, and have not been treated with a combination of mood stabilizers or antipsychotic medication; (4) Have at least elementary school education and be able to cooperate in completing cognitive function tests and clinical assessments; (5) No history of serious substantial organ as well as metabolic abnormalities or endocrine diseases; (6) A total HAMD-17 score of 17-24 at baseline at the time of enrollment; (7) The consent of the patients and their families should be obtained and an informed consent form should be signed.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) Patients with depressive disorders accompanied by psychotic symptoms, patients with suicidal tendencies; (3) Patients with severe physical illnesses, such as severe liver or kidney disease, heart disease, hypertension, diabetes, thyroid disease, etc. (4) A history of psychoactive substance abuse or taking any medication that may affect cognitive function (e.g., glucocorticoids, beta-blockers, opioid analgesics, and central stimulants).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metacognition;Glutamic acid;aspartic acid;glutamine;N-acetylaspartic acid;glycine;gamma-aminobutyric acid;tryptophan;histidine;tyrosine;phenylalanine;deoxycholic acid;valine;alanine;proline;argnine;leucine ;isoleucine;creatine;fleshiness;palmitoleic acid;asparagine; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD-17 Depression Scale; | — |
Countries
China
Contacts
Public ContactMing Tao
Zhejiang University of Chinese Medicine
Outcome results
None listed