Lung ischemia-reperfusion injury
Conditions
Interventions
Control group:The control group inhaled 4 ml of physiological saline as soon as two- lung ventilation started . When starting single lung ventilation,the control group inhaled 2ml of physiological sa
Test group:The test group inhaled dexmedetomidine 1ug/kg (the total solution was 4ml) when two-lung ventilation began. When starting single lung ventilation,dexmedetomidine (0.5ug/kg,the total solutio
Sponsors
Department of Anesthesiology, Civil Aviation General Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: Patients diagnosed with lung cancer in thoracic surgery who are to undergo lobectomy, segmental resection or wedge resection 2:30-75 years old 3:ASA Class II-III 4:Single lung ventilation for 1-3 hours 5:18.5<BMI <23.9 6:Sign relevant informed consent forms.
Exclusion criteria
Exclusion criteria: 1: Patients with total lung resection, emergency thoracotomy, mechanical ventilation without extubation after surgery, recent use of antioxidants (such as vitamin E preparations), and serious medical complications or complications 2: The investigator believes that there are subjects who are not eligible for participation in this trial for other factors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total antioxidant status,TAS;mtDNA copy number;Glutathione peroxidase 4 (GPX4) protein;The concentration of Fe2+ in macrophages;The expression of glutathione peroxidase 4 (GPX4) protein in macrophages;Total oxidative status,TOS;Oxidative stress index,OSI;Malondialdehyde,MDA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percutaneous arterial oxygen saturation;Heart rate ;Mean arterial pressure,MAP;The time of one-lung ventilation;Postoperative quality of life scale for thoracoscopic surgery; | — |
Countries
China
Contacts
Public ContactLihua Du
Civil Aviation General Hospital
Outcome results
None listed