overweight/obese
Conditions
Interventions
caloric restriction diet:caloric restriction diet
high protein diet:high protein diet limited energy
caloric restriction diet+probiotic:caloric restriction diet+probiotic
high protein diet+probiotic:high protein diet limited energy +probiotic
Sponsors
Ningxia Hui Autonomous Region People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: Age at 18-65 years (including 18 years and 65 years old) 2: BMI 24.0-40.0kg/m^2 3: spiritual and cognitive normal, can complete basic communication and communication, can cooperate with research 4: willingness to be willing Sign the project "Inspector Consent" 5: Living in the local area for at least one year.
Exclusion criteria
Exclusion criteria: 1: There are serious diseases such as heart, liver and kidney, or organs, systems and other diseases, or are currently undergoing severe cardiovascular, immunity, breathing, hepatobiliary, kidney and urology, nerves, muscle skeletal, mental, infection and malignant diseases 2: There are gastrointestinal diseases (such as constipation, diarrhea, abdominal pain, intestinal excitement syndrome, and inflammatory bowel disease) 3: Drugs (inhibitors and appetite inhibitors) and probiotic products that affect weight in the past month 4: Recently (over the past 2 months) or continuous use of antibiotics 5: pregnancy and lactation women 6: plan to participate in other clinical trials 7: investigators who believe it is inappropriate for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight;Waist circumference;Gut microbiota High-throughput sequencing;Body Composition Indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood lipid indicators;Liver and kidney function;eating habits;Psychological survey; | — |
Countries
China
Contacts
Public ContactZhao Qian
Ningxia Hui Autonomous Region People's Hospital
Outcome results
None listed