hepatocellular carcinoma
Conditions
Interventions
Patients Within MC (I-MC):NA
Sustained Disease Control (S-DC):NA
Other Beyond-MC Patients (B-MC):NA
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age >18; 2. Imaging-confirmed diagnosis of primary HCC, or recurrent HCC that has undergone radical resection or radiofrequency ablation; 3. Liver transplantation at any study center during 2016-2023 with complete and available perioperative clinical data, with or without downstaging or bridging therapy; 4. Imaging data before and after downstaging are available and response to therapy can be assessed by mRECIST; 5. The tumor has no extrahepatic metastases; 6. Post-transplantation follow-up data are available.
Exclusion criteria
Exclusion criteria: 1. Age 2cm); 3. Incidentally discovered hepatocellular carcinoma; 4. Postoperative pathological diagnosis of intrahepatic cholangiocarcinoma, mixed hepatocellular carcinoma, or other liver malignancy; 5. Missing perioperative clinical data, imaging data before and after downstaging, or post-transplant follow-up data; 6. HIV-infected patients, severe active infections other than HBV and HCV, prior history of other malignancies, history of alcohol or other drug abuse; 7. Patients with cardiopulmonary function that cannot tolerate surgical treatment, patients with severe psychosomatic disorders, history of severe drug allergy to contrast media, anesthetics, sedatives, etc.; 8. Life expectancy < 3 months due to HCC or < 6 months due to any other disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor-specific survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Recurrence-free survival;Recurrence rate;Tumor-specific death;Peri-transplant death;Post-transplant infection;Acute hepatic insufficiency, with suspected rejection;Biopsy-proven acute rejection ;Biopsy-proven chronic rejection ; | — |
Countries
China
Contacts
Public ContactKunlin Xie
West China Hospital, Sichuan University
Outcome results
None listed