Postoperative acute pain
Conditions
Interventions
Experimental group:The pectoralis major intercostal muscle block was performed with Exparel
Intervention group:The pectoralis major intercostal muscle block was performed with ropivacaine
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Before the test, understand the nature, significance, possible benefits, possible inconveniences and potential dangers of the test in detail, understand the research procedure and sign the informed consent in person. 2) Patients who plan to undergo elective valve replacement (mitral valve replacement or aortic valve replacement) are operated by the same group of physicians 3) Male and female, age 20-70 years old 4) Male weight =50?, female weight =45?, BMI19.0 ~ 26.0kg/m^2 5) ASA grade ?-? 6) Grade II or III cardiac function, preoperative left ventricular ejection fraction (LVEF) > 40%
Exclusion criteria
Exclusion criteria: 1) The patient refused to participate in the study 2) Previous history of specific allergic diseases (asthma, urticaria, eczema, etc.) or local anesthetics 3) Damage or infection in the chest wall area 4) Abnormal coagulation function, patients with APTT > 33.8s or PT > 12.1s before surgery (33.8 and 12.1 are the reference intervals set by the clinical laboratory of our hospital according to the current normal control value 25.2 and 10.9, respectively, if the normal control value changes, the reference interval will also change accordingly) 5) Complicated coronary heart disease, need intra-aortic balloon counterpulsation support or congestive heart failure 6) Liver and kidney failure 7) History of drug abuse, history of chronic pain, history of mental illness 8) Emergency surgery or secondary surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of pain score within 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| 3ml of venous blood was collected before surgery and 1, 2 and 3 days after surgery to detect plasma angiotensin and interleukin6.;The intraoperative dosage of sufentanil, remifentanil and propofol were recorded.;MAP and HR before anesthesia induction, when skin was cut, when sternum was performed, at the beginning of the transfer, at the end of the transfer, 24h and 72h after surgery.;The number of effective analgesic pump compressions was recorded from 12 h, 12 ~ 24h and 24 ~ 48h after surgery.;Extubation time of the patient;Length of stay in ICU;Postoperative exhaust defecation time;Incidence of postoperative pruritus;Time when patients first get out of bed;The incidence of postoperative nausea and vomiting and the use of antiemetic drugs;Length of postoperative hospital stay;Postoperative sleep quality of patients;Popc postoperative pulmonary complications;Patients recovered quality at days 1, 2, 3, and 7; | — |
Countries
China
Contacts
Public ContactShibiao Chen
The First Affiliated H{ospital of Nanchang University
Outcome results
None listed