Lschemic stroke
Conditions
Interventions
Standard medical therapy and tenecteplase group:NA
Sponsors
Second Affiliated Hospital of Army Medical University, PLA
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age =18 years; 2) Preliminary diagnosis of acute ischemic stroke according to clinical symptoms and signs; 3) Acute ischemic stroke confirmed by CT/MRI; 4) Thrombolysis with tenecteplase; 5) Patients or their family members provided written informed consent.
Exclusion criteria
Exclusion criteria: 1) Intracranial hemorrhage confirmed by head CT or MRI; 2) Expected inability to complete follow-up; 3) Patients who were deemed unsuitable for study participation by the investigator; 4) Active internal bleeding; 5) Significant bleeding illness currently or in the past 6 months; 6) Known or suspected history of intracranial hemorrhage; 7) Known bleeding constitution; 8) Significant or recent severe or dangerous bleeding; 9) A history of central nervous system disease or trauma (e.g., intracranial tumor, arteriovenous malformation or aneurysm, intracranial or intraspinal surgery); 10) Aneurysmal subarachnoid hemorrhage or suspected subarachnoid hemorrhage; 11) Tumors with a tendency to bleed; 12) Bacterial endocarditis or pericarditis; 13) A recent (within 2 weeks) prolonged (>2 minutes) cardiopulmonary resuscitation, delivery, or nonpressure vessel puncture (e.g., subclavian or jugular venepuncture); 14) Acute pancreatitis, active gastrointestinal ulcer, aneurysm or arterial/venous malformation; 15) Oral anticoagulant therapy and INR>1.3; 16) Severe liver disease, including liver failure, cirrhosis, portal hypertension (esophageal varices), and active hepatitis; 17) Severe trauma or major surgery in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mRS Score;Incidence of symptomatic intracranial hemorrhage;90-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of 90-day mRS Scores 0-2;The proportion of 90-day mRS Scores 0-1;Changes of NIHSS score 5-7 days after surgery;90-day EQ-5D scale score;incidence of asymptomatic intracranial hemorrhage;Incidence of non-intracranial hemorrhage complications;Incidence of non-hemorrhagic serious adverse events; | — |
Countries
China
Contacts
Public ContactWenjie Zi
Second Affiliated Hospital of Army Medical University, PLA
Outcome results
None listed