The effect of different Cryotherapy regimens on blood flow velocity in the femoral and popliteal veins of the lower extremities after total knee arthroplasty

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400091195

Enrollment

Unknown

Registered

2024-10-23

Start date

2024-11-01

Completion date

Unknown

Last updated

2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty

Interventions

Group C:Immediate postoperative cold therapy was given for 6h at 10?-15?

on postoperative days 1-7, cold therapy for 2h, 4 times a day: 7:00-9:00,11:00-13:00,15:00-17:00,19:00-21:00.

Group A:Immediate postoperative cold therapy was administered for 0.5 h at intervals of =1 h at 10°C-15°C four times a day: 7:00-7:30,11:00-11:30,15:00-15:30,19:00-19:30, and intervened until postoper

Group B:Immediate postoperative cold therapy for 6h at 10?-15?

on postoperative days 1-7, cold therapy for 2h, 4 times a day: 7:00-9:00,11:00-13:00,15:00-17:00,19:00-21:00.Immediate postoperative cold therapy for 6h at 10?-15?

on postoperative days 1-7, cold therapy was given for 3h, three times a day: 7:00-10:00,13:00-16:00,18:00-21:00.

control group:general nursing

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ?First-time unilateral TKA with the same physician group of surgeons ?Age 40 = age = 75, male or female; ?Aware and able to communicate effectively; ?Those with no previous history of open trauma or surgery to the affected knee

Exclusion criteria

Exclusion criteria: ?Combined severe heart, liver, kidney and other organ dysfunctions ?Persons with coagulation or haematological disorders ?Those with malignant tumours ?Those with pre-existing preoperative lower limb DVT ?Comorbidities of the circulatory system ? Preoperative lower limb venous valve insufficiency; ?Those using antiplatelet drugs and anticoagulants within 2 weeks before surgery ?Sensory impairment in patients with nerve damage to the lower limb on the operated side ?Those with drug contraindications, cold allergies or other reasons not suitable for this study

Design outcomes

Primary

Measure	Time frame
Mean blood flow velocity in the femoral and popliteal veins of the lower extremities;	—

Secondary

Measure	Time frame
Pain;Surgical Wound Swelling Value;Hospital for Special Surgery;Volume of drainage fluid;White blood cell, WBCPercentage of neutrophils, NEUT%erythrocyte sedimentation rate, ESR)C-reactive protein, CRP;	—

Countries

China

Contacts

Public ContactGuoshengming

The Affiliated Hospital of Southwest Medical University

2930773281@qq.com+86 139 8025 5653

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026