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Endogenous Lactate Accumulation in Schizophrenia: A Potential Association with Aberrant Activation of the NLRP3/Caspase-1/IL-1ß Inflammatory Signaling Pathway

Establishment and mechanism of a novel schizophrenia model in tree shrews

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400091186
Enrollment
Unknown
Registered
2024-10-22
Start date
2024-10-30
Completion date
Unknown
Last updated
2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia

Interventions

Sponsors

Yunnan Provincial Psychiatric Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for patients with schizophrenia: the diagnosis of patients strictly followed the diagnostic criteria for schizophrenia in the Diagnostic and statistical manual of mental disorders, Fourth edition (DSM-V) of the United States of America; age 18-60 years old; sex No limitation; Han nationality was chosen for all ethnic groups.

Exclusion criteria

Exclusion criteria: Exclusion criteria for patients with schizophrenia: no history of mental retardation or other psychiatric disorders; no history of infection or abuse of alcohol and/or psychoactive substances prior to one week; no viral encephalitis, diabetes mellitus, thyroid dysfunction, hypertension, fatty liver, gout, cardiac failure, renal failure, or other medical illnesses; exclusion of wheelchair-bound/bedridden/feeding-disordered patients, pregnant/lactating female patients and patients who have used/are using medications related to lowering blood glucose, blood lipids or blood pressure.

Design outcomes

Primary

MeasureTime frame
Lactate;

Secondary

MeasureTime frame
LDH;glucose;triglyceride;low-density lipoprotein;positive and negative syndrome scale, PANSS;

Countries

China

Contacts

Public ContactTianhao Bao

Yunnan Provincial Psychiatric Hospital

doctor@kmmu.edu.cn+86 137 0065 7351

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026