Central nervous system infection
Conditions
Interventions
Pathogen diagnosis optimization strategy group:NA
Pathogen diagnosis routine strategy group:NA
Sponsors
Beijing Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: Project 1: Optimization and implementation evaluation of a multicenter strategy for pathogenic diagnosis of CNS infections in children. (1) suspected bacterial meningitis in children, in line with the World Health Organization (WHO) bacterial meningitis surveillance case classification criteria improved: ? 28 days after birth to 18 years old; ? acute onset of disease; ? fever (axillary temperature = 38 ° C) and or the following clinical signs: headache, altered consciousness, refusal to breastfeeding, vomiting, irritability, lethargy, hypotonia, convulsive episodes, fontanel full or bulging, more than one Clinical signs of meningitis; ? one of the following two conditions: cerebrospinal fluid routine WBC > 100 / ml; or cerebrospinal fluid routine WBC 10 ~ 100 / ml and changes in the appearance of cerebrospinal fluid or glucose 100mg / dl. (2) suspected childhood encephalitis criteria: ? 28 days to 18 years old; ? acute onset of the disease; ? fever and meet the one of the following Headache, vomiting, convulsions, impaired consciousness; ? Cerebrospinal fluid cell count =15/ml. Project 2: Construction and validation of a "host biomarker combined with clinical microbiology pathogen diagnostic model" for pediatric CNS infection. (1) suspected bacterial meningitis in children, in line with the World Health Organization (WHO) bacterial meningitis surveillance case classification criteria improved: ? 28 days after birth to 18 years old; ? acute onset of disease; ? fever (axillary temperature = 38 ° C) and or the following clinical signs: headache, altered consciousness, refusal to breastfeeding, vomiting, irritability, lethargy, hypotonia, convulsive episodes, fontanel full or bulging, more than one Clinical signs of meningitis; ? one of the following two conditions: cerebrospinal fluid routine WBC > 100 / ml; or cerebrospinal fluid routine WBC 10 ~ 100 / ml and changes in the appearance of cerebrospinal fluid or glucose 100mg / dl. (2) suspected childhood encephalitis criteria: ? 28 days to 18 years old; ? acute onset of the disease; ? fever and meet the one of the following Headache, vomiting, convulsions, impaired consciousness; ? Cerebrospinal fluid cell count =15/ml.
Exclusion criteria
Exclusion criteria: Project 1: Optimization and implementation evaluation of a multicenter strategy for pathogenic diagnosis of CNS infections in children. 1. cases of autoimmune encephalitis; 2. tumors with central nervous system involvement; 3. cases with bloody cerebrospinal fluid; 4. the volume of cerebrospinal fluid was less than 1ml; 5. Children who refused to be enrolled for various reasons; Project 2: Construction and validation of a "host biomarker combined with clinical microbiology pathogen diagnostic model" for pediatric CNS infection. 1. cases of autoimmune encephalitis; 2. tumors with central nervous system involvement; 3. cases with bloody cerebrospinal fluid; 4. the volume of cerebrospinal fluid was less than 1ml; 5. children who refused to be enrolled for various reasons; 6.those with a clear pathogenic diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathogen detection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total length of stay;clinical outcome;The duration of pathogen diagnosis;use of antibiotics;general expenses;Accuracy;Precision;Recall;F1 Score; | — |
Countries
China
Contacts
Public ContactLiu Gang
Beijing Children's Hospital
Outcome results
None listed