catheter-related bladder irritation(CRBD)
Conditions
Interventions
D Group:Intravenous injection of dexmedetomidine 0.2µg/kg at 1 minute
DLB Group:Intravenous injection of dexmedetomidine 0.2µg/kg and butorphanol tartrate 10ug/kg at 1 minute
DHB Group:Intravenous injection of dexmedetomidine 0.2µg/kg and butorphanol tartrate 20ug/kg at 1 minute
Sponsors
Department of Anesthesiology, Yijishan Hospital, Wannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-70 years old, male or female (2) ASA Grade I-III (3) Patients with catheterization after general anesthesia induction (4) Sign informed consent
Exclusion criteria
Exclusion criteria: (1) Patients with bladder outflow tract obstruction, urinary tract infection, neurogenic bladder and prostatic hyperplasia (2) Patients taking anti-inflammatory drugs, opioid analgesics, sedatives, antidepressants, immunomodulators and other drugs for a long time (3) Patients with a history of cerebrovascular disease, cardiovascular disease, and mental illness (4) Patients with severe liver and kidney diseases and severe conduction block (5) Patients with severe impairment of hearing or communication or cognitive function (6) Patients who are also participating in other trial studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission of CRBD within 30 minutes of administration in all three groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRBD remission at 1 hour, 6 hours, and 24 hours of administration in three groups;NRS scores were obtained for 0 minutes, 5 minutes, 15 minutes, 30 minutes, 1 hour, 6 hours, and 24 hours;Three groups of patients were given 0 minutes, 5 minutes, 15 minutes, 30 minutes, 1 hour, 6 hours, 24 hours of SAS scores;Mean arterial pressure, heart rate, and pulse oxygen saturation were measured at 0 minutes, 5 minutes, 15 minutes, 30 minutes, 1 hour, 6 hours, and 24 hours;The incidence of respiratory depression (SpO2<90%), nausea and vomiting, dry mouth, chills and delirium, dizziness and headache after administration in the three groups;15 Quality of recovery scores (QoR-15) 24 hours after surgery in all three groups; | — |
Countries
China
Contacts
Public ContactWang Yulong
Department of Anesthesiology,Yijishan Hospital, Wannan Medical College
Outcome results
None listed