Gastrointestinal cancer
Conditions
Interventions
experimental group:Esketamine
Sponsors
he Second Affiliated Hosipital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing gastrointestinal tumor surgery under general anesthesia; (2) The American Society of Anesthesiologists (ASA) classifies it as Grade I~III; (3) Normal liver and kidney function, cardiopulmonary function tests suggest that the operation can be tolerated; (4) Age = 60 years old; (5) Body mass index (BMI) within the range of 18.0-30.0kg/m^2; (6) Proficient in using PCIA pumps; (7) Can understand and fully cooperate in using various postoperative scoring tools
Exclusion criteria
Exclusion criteria: (1) Combined severe cardiovascular and cerebrovascular disease; (2) Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure >180/100mmHg); (3) Untreated or inadequately treated hyperthyroidism; (4) Liver and kidney dysfunction, combined with severe organ damage; (5) Consciousness disorders or severe mental or central nervous system disorders; (6) Having cognitive impairment or poor comprehension ability,and unable to communicate effectively; (7) Long term use of sedative, hypnotic, and analgesic drugs, or drug abuse; (8) Heart rate<50 beats/min or with III degree atrioventricular block; (9) Known to be allergic to experimental anesthetics; (10) Have experienced unstable angina or myocardial infarction in the past 6 months; (11) High intraocular pressure (glaucoma) or eye trauma; (12) Transfer to ICU after surgery; (13) Patient's data loss during perioperative period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The total number of times the analgesic pump is pressed;Additional dosage if pain is still felt;Postoperative nausea and vomiting;Ramsay score;Buchholz Comfort Score;overall satisfaction;Incidence of bradycardia;Psychological adverse reactions; | — |
Countries
China
Contacts
Public ContactLi Xiaoxia
The Second Affiliated Hosipital of Chongqing Medical University
Outcome results
None listed