resistant hypertension
Conditions
Interventions
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: (1) Despite the use of three antihypertensive drugs at tolerable and sufficient doses (including a thiazide diuretic, with the other two being any of the five major classes of antihypertensive drugs recommended by the "2018 Chinese Guidelines for the Prevention and Treatment of Hypertension" [calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), diuretics, and beta-blockers], this study will also consider other drug types such as aldosterone receptor antagonists and alpha-blockers), blood pressure remains above the target level (office blood pressure measured on three different occasions shows systolic blood pressure =140 mmHg and/or diastolic blood pressure =90 mmHg, with a 24-hour average blood pressure >130/80 mmHg); (2) Age between 18 and 79 years; (3) Signed informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with a confirmed diagnosis of secondary hypertension; (2) Patients with severe heart failure (New York Heart Association [NYHA] Class 3-4); (3) Patients with acute myocardial infarction; (4) Patients in the acute phase of stroke; (5) Patients with severe liver dysfunction (ALT > 3 times the upper limit of normal and BIL > 2 times the upper limit of normal); (6) Patients with severe renal failure (eGFR < 30 mL/1.73 m²); (7) Patients with congenital heart disease; (8) Patients with malignant tumors or severe infections; (9) Pregnant or breastfeeding women; (10) Patients participating in other clinical studies; (11) Patients unable to provide informed consent; (12) Patients deemed unsuitable for enrollment or unable to complete follow-up according to the judgment of the physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SBP;DBP; | — |
Secondary
| Measure | Time frame |
|---|---|
| BP out of office ; | — |
Countries
China
Contacts
Public ContactYuqing Zhang
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed