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Chronic Stress, non-suicidal self-injury, and pain aberrations: exploring the interaction of psychoneuroimmunological mechanisms

Neuroendocrine-immune mechanisms in chronic stress-induced hyperalgesia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400091131
Enrollment
Unknown
Registered
2024-10-21
Start date
2024-10-26
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hyperalgesia

Interventions

No history of NSSI group:NA
Control group:NA

Sponsors

Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: (1) Participants should be between the ages of 18 and 30; (2) Reporting chronic stress experiences, such as long-term academic pressure, family issues, or other personal problems; Participants should self-report experiencing persistent or recurrent pain in the past 6 months that they believe is related to their stress. Psychological assessments should indicate stress-related psychological reactions, such as elevated perceived stress levels; (3) Healthy individuals with normal physical examination findings and good overall health status who are able to participate in all study procedures; (4) Willingness to participate in the study and ability to provide informed consent.

Exclusion criteria

Exclusion criteria: (1) History of major chronic diseases such as cardiovascular disease, diabetes, or long-term use of immunosuppressants, hormonal drugs, or other medications that may affect pain perception or stress response; (2) History of severe mental illness, such as schizophrenia, major depressive disorder, or currently undergoing psychotherapy; (3) Presence of neurological disorders that could interfere with pain assessment or data interpretation; (4) Physical or psychological conditions that make the participant unsuitable for participation in questionnaires or clinical assessments.

Design outcomes

Primary

MeasureTime frame
Pain sensitivity;Glucocorticoid Levels;Inflammatory markers;Leukocyte subsets;

Secondary

MeasureTime frame
Chronic stress;Non-suicidal self-injury (NSSI);

Countries

China

Contacts

Public ContactXueling Yang

Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China

shirling@smu.com+86 186 6500 0250

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026