parkinson disease
Conditions
Interventions
Gold Standard:PD: Meets the 2015 MDS diagnostic criteria of Parkinson's disease and the 2016 version of Chinese diagnostic criteria of Parkinson's disease.
PDS :Meets the criteria of Parkinson's syndr
Index test:Cutaneous silent periods
Sponsors
Guangdong Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: PD group. 1) meet the 2015 International Association of dyskinesia (MDS) Parkinson's Disease Diagnostic criteria and the 2016 version of Chinese Parkinson's Disease Diagnostic criteria; 2) the age is 50-70 years old, the course of disease is less than 5 years, and the H&Y stage = II stage; 3) volunteer to participate in this researcher and could cooperate in completing all examination items. Control group. Normal middle-aged and elderly people aged 50-70 without nervous system and peripheral nerve damage. PDS group. 1)Meets the criteria of Parkinson's syndrome in the 2016 edition of Chinese Parkinson's Disease Diagnostic criteria, and there is at least one absolute exclusion criterion for Parkinson's disease. 2) the age was 50-70 years old, the course of disease was less than 5 years, and the H&Y stage was = II. 3) voluntarily participated in this researcher and could cooperate to complete all the examination items
Exclusion criteria
Exclusion criteria: 1) patients with pacemakers or other conditions are not suitable for electrophysiological examination, 2) patients with a clear history of peripheral neuropathy, 3) patients with diabetes, alcohol dependence or drug addiction, 4 ) patients with rheumatic immune diseases, HIV infection, history of gastrointestinal surgery and severe damage of liver and kidney function. ? Patients who undergo surgical implantation of electrodes for deep brain stimulation therapy; Same as the first part.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| duration;end latency;AUC; | — |
Secondary
| Measure | Time frame |
|---|---|
| onset latency;sympathetic skin responses;sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactXie Chunge
Guangdong Provincial People’s Hospital
Outcome results
None listed