burst suppression and postoperative cognitive function
Conditions
Interventions
Control group:0.9% Sodium Chloride solution
Sponsors
Anhui NO.2 Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age range of 60-85 years old; 2.BMI:18.5-27.0; 3.ASA grades I-III and cardiac function grades I-II; 4. Patients with normal liver and kidney function, and patients with normal coagulation function; 5. Fully understand the purpose and significance of this trial, as well as the voluntary signing of informed consent by the patient's family members.
Exclusion criteria
Exclusion criteria: 1. Patients with neurological disorders and those taking psychiatric medications 2. Patients with severe hypertension, intracranial hypertension, high intraocular pressure, and a history of cerebrovascular accidents 3. Patients with hyperthyroidism and adrenal pheochromocytoma 4. Patients with heart dysfunction, history of coronary artery disease, cardiomyopathy, or angina pectoris 5. Determine/suspect the abuse or long-term use of anesthetic sedatives and analgesics; Contraindications for the use of ketamine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and frequency of burst suppression ;Postoperative cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| PSI value of anesthesia depth at each time point;Visual simulation pain score and number of analgesic pump presses within 48 hours after surgery; | — |
Countries
China
Contacts
Public ContactWang Yiqiao
Anhui No.2 Provincial People’s Hospital
Outcome results
None listed