ARDS caused by trauma (except burns)
Conditions
Interventions
Cevelestat sodium + conventional treatment group:None
Control group:None
Sponsors
Fourth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 75 years (inclusive), with no restriction on gender; 2) Definite trauma is needed; 3) Diagnosed with ARDS within 48h using the New Global Definition of ARDS(2023).
Exclusion criteria
Exclusion criteria: 1)Pregnancy or lactatating women; 2)Patients diagnosed with cardiogenic pulmonary edema; 3)Patients diagnosed with chronic lung diseases, including chronic obstructive pulmonary disease (COPD), bronchiectasis, etc; 4)Patients use ulinastatin or xuebijing injection during the study; 5)Patients using glucocorticoids >= 1mg/kg/d within 7 days before included; 6)Patients with 4 or more organ injuries and organ failure or single extra-pulmonary organ SOFA score >= 3; 7)Patients with an APACHE II score>25; 8)Patients diagnosed with malignant tumors, end-stage lung diseases, cachexia, near-death and other end-stage diseases; 9) Patients who refuse to participate or have been included in other trials; 10)Patients judged by the investigator to be unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein content in blood ;Procalcitonin levels in blood ;Interleukin-6 levels in blood ;Interleukin-8 levels in blood ;TNF-a levels in blood ;NEU% in blood;WBC in blood;D-Dimer in blood plasma;Lung compliance;Breathing machine PEEP;28-day survival rate; | — |
Countries
China
Contacts
Public ContactGuo Jianying
Fourth Medical Center of PLA General Hospital
Outcome results
None listed