Gastrointestinal tumors
Conditions
Interventions
Intervention Group:Intravenous injection of 0.3mg/kg of ketamine during anesthesia induction
Conrol group:Intravenous injection of normal saline during anesthesia induction
Sponsors
Changzhi People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Elderly patients over 60 years old; (2) Clear consciousness and no abnormal mental state (3) ASA level I-III; (4) Selective surgery; (5) Agree to use postoperative intravenous patient-controlled analgesia. (6) PHQ score>5 points (7) Voluntary signing of informed consent form
Exclusion criteria
Exclusion criteria: (1) Taboos for the use of ketamine (such as grade 3 hypertension, hyperthyroidism, severe heart disease allergies); (2) Sleep apnea syndrome; (3) Intraoperative blood loss = 500ml; (4) Communication barriers; (5) Previously known during surgery; (6) Preoperative concurrent chronic pain; (7) Postoperative admission to the intensive care unit for treatment (8) Patients with a history of dementia or mental illness, or those taking antipsychotic or antidepressant drugs at home
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depressed;Sleep monitoring; | — |
Secondary
| Measure | Time frame |
|---|---|
| BDNF;5-HT;TNF-a;IL-6;Adverse reactions within 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactJianing Bo
Changzhi People's Hospital
Outcome results
None listed