Mechanically ventilated patients admitted to ICU
Conditions
Interventions
Rimazolam group :Rimazolam group:the sedative medication consisted of a continuous infusion of remimazolam besylate (Yichang Renfu Pharmaceutical, China) at a dosage of 0.1 mg/(kg·h).
propofol group.:The propofol group received an initial intravenous loading dose of propofol (1-2 mg/kg) (Nhwa Pharmaceutical Co., Jiangsu, China), followed by a continuous infusion of propofol at a ra
Sponsors
Affiliated Hospital of Yanbian University.
Eligibility
Sex/Gender
All
Age
28 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1.age = 18 years old. 2.patients with ICU mechanical ventilation. 3.Obtain the informed consent of the patient or family member.
Exclusion criteria
Exclusion criteria: 1. age =18 year. 2. Pregnancy or lactation. 3. Severe, pre-existing parenchymal liver disease with clinically significant portal hypertension, Child-Pugh C grade liver cirrhosis, or acute liver failure. 4. Patients with bronchial asthma or myasthenia gravis. 4. Patients with bronchial asthma or myasthenia gravis. 5. Patients with a history of alcohol or drug abuse. 6. Any condition that impedes proper assessment of cognitive function, such as language and sensory disorders or mental disorders (language difficulties or organic mental disorders). 7. BMI 35 kg/m^2. 8. There is a history of using monoamine oxidase inhibitors within 14 days, such as phenylethylhydrazine, isoniazid, etc. 9. Unable to obtain informed consent or authorization. 10. Participate in other exploratory clinical trials within 6 months before screening. 11. Allergic to experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glutamic pyruvic transaminase;glutamic oxaloacetic transaminase;Triglyceride;Incidence of delirium;mean arterial pressure;creatinine;Cholesterol;Low-density lipoprotein;high-density lipoprotein; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay (days);mechanical ventilation time (H), ;sedative medication time (H), ;sedative medication dosage (mg); | — |
Countries
China
Contacts
Public ContactMinggen Jin
Affiliated Hospital of Yanbian University
Outcome results
None listed