temporomandibular joint osteoarthritis
Conditions
Interventions
HA injection group (Control):Sodium hyaluronate was injected into the upper cavity of the TMJ of the affected side after irrigation, and the patient was instructed to perform open and close mouth move
PRP injection group (Experimental 1):After irrigation of the upper cavity of the affected TMJ, autologous platelet-rich plasma was injected into 0.6-0.8 mL, and the patient was instructed to perform
PRP +HA injection group (Experimental 2):After irrigation of the upper cavity of the affected TMJ, autologous platelet-rich plasma or hyaluronic acid was injected 0.6-0.8 mL. 1st injection of autolog
Sponsors
Affiliated Stomatological Hospital of GuangXi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 65 years; (2) Presence of joint pain that worsens with functional activity; (3) The presence of joint pressure points on palpation; (4) The presence of degenerative changes on CBCT, such as condylar breakthrough, osteophytes, cystic degeneration, and shortening; (5) MRI examination of the temporomandibular joint region in the open and closed positions diagnosed as irreducible anterior disc displacement.
Exclusion criteria
Exclusion criteria: (1) Individuals with immune system disorders and haematological disorders, including rheumatoid arthritis, idiopathic thrombocytopenic purpura, anaphylactic purpura, thrombotic thrombocytopenic purpura, haemophilia and diffuse intravascular coagulation, will be included in the study. (2) The administration of a therapeutic intervention for a diagnosis of temporomandibular joint disorder within the previous three months. (3) A history of surgical intervention on the temporomandibular joints. (4) A history of neoplastic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The condylar damage index;The condylar remodeling index;Maximum opening;Pain scores in the articular region;Articular noise;Interleukin-1 beta;Tumor necrosis factor-a;Interleukin-6;Matrix metalloproteinas;Growth factor;blood platelet concentration; | — |
Countries
China
Contacts
Public ContactNong Xiaolin
Affiliated Stomatological Hospital of Guangxi Medical University
Outcome results
None listed