Transthyroxin protein amyloid cardiomyopathy
Conditions
Interventions
TTR Normal group:None
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 =90 years old; 2. ATTR-CA high-risk patients, as defined in the 2021 European Society of Cardiology (ESC) Position Statement on the Diagnosis and Treatment of cardiac amyloidosis and the 2023 American College of Cardiology (ACC) Expert Consensus on cardiac amyloidosis, Patients whose left ventricular wall thickness indicated by echocardiography was =12mm and met =1 warning sign of ATTR-CA were defined as ATTR-CA high-risk patients. 3. Sign informed consent, voluntarily participate in the experiment, and agree to participate in visits, examinations, and treatments according to the requirements of the research protocol
Exclusion criteria
Exclusion criteria: 1. Subjects in the tumor active stage, severe infection, acute inflammation, renal failure, severe liver function impairment, and patients who have experienced acute coronary syndrome, unstable angina pectoris, stroke, transient ischemic attack, coronary revasulation, cardiac device implantation, heart valve repair, or major surgery due to worsening heart failure within 1 month; 2. Subjects who have previously received liver and/or heart transplants; (3) Women who are pregnant or breastfeeding; 4. A combination of acute or chronic medical or psychiatric conditions, including recent (within the past year) combination of active suicidal ideation or behavior or abnormalities in laboratory tests, that may increase the risk of adverse events for study participants or interfere with study findings, and are judged by the investigator to be unsuitable for inclusion in the study; 5. Abnormal serum free light chain ratio (?/? 1.65); 6. Abnormal monoclonal immunoglobulin was found by immunofixation electrophoresis of serum protein; 7. Consider other subjects with secondary amyloidosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular death;Cardiovascular rehospitalization; | — |
Countries
China
Contacts
Public ContactYing Liu
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed