Breast cancer
Conditions
Interventions
Group A:After induction of anesthesia, 0.25mg/kg esketamine was injected intravenously for 40min (esketamine diluted into 20ml normal saline).
Group B:After induction of anesthesia, 0.5ug/kg dexmedetomidine was injected intravenously for 40min (diluted into 20ml normal saline).
Group C:After induction of anesthesia, 0.25mg/kg esketamine +0.5ug/kg dexmedetomidine was injected intravenously for 40min (diluted into 20ml normal saline).
Group D:Constant dose of normal saline was pumped continuously after induction of anesthesia
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ?ASA grade I-II; ? Age 18-65 years old; ?18=BMI < 28kg/?; (4) To perform modified radical mastectomy at selected time; ? Sign informed consent.
Exclusion criteria
Exclusion criteria: A history of allergy to ketamine, dexmedetomidine, or opioids; ? Patients with uncontrolled hypertension, diabetes, serious heart, lung, brain, liver, kidney and other chronic diseases; (3) Preoperative history of major depression (SDS standard score > 72 is major depression, in which depression is diagnosed and graded according to SDS) or other psychiatric diseases; ? Poor comprehension or cognitive dysfunction; (5) Preoperative VAS score > 2 points; ? Alcoholism and long-term use of sedatives or analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-rating Depression Scale (SDS) score;The incidence of agitation, delirium and other adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery Q-15 score;VAS score; | — |
Countries
China
Contacts
Public ContactJianqing Lin
The First Affiliated Hospital of Fujian Medical University,
Outcome results
None listed