hospital-acquired pneumonia
Conditions
Interventions
Control group:Nebulized inhalation of 0.9% NaCl solution 3-4 mL + receive standard combination regimen for = 14 days, recommended standard treatment regimens are as follows:
Polymyxins + tigecycline/c
Experimental group:Received CMS nebulized inhalation therapy (75 mg/dose, q12h) + standard combination regimen for = 14 days
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Voluntarily participated in this study and signed an informed consent form; (2) Hospitalized patients aged =18 years old, regardless of gender; (3) Clinical and respiratory secretion bacteriologic examination results confirmed CRAB infection; (4) Those who met the diagnostic criteria for HAP (diagnostic criteria refer to the 2018 edition of the Chinese Guidelines for the Diagnosis and Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia in Adults); (5) Respiratory specimens for culture were obtained within 72 h prior to randomization into groups and after the onset of signs and symptoms of pneumonia (ideally before receiving any antibiotics)
Exclusion criteria
Exclusion criteria: (1) Consider CRAB for colonization; (2) Combination of other sites of infection or multiple pathogens in addition to the lungs; (3) Patients with a history of severe allergy or hypersensitivity to the drugs used in this study; (4) Combined with malignant tumors, hematologic diseases and other serious diseases; (5) Patients with known or suspected active tuberculosis, cystic fibrosis, lung abscess or obstructive pneumonia; (6) Those who have used polymyxin-based nebulized inhalation therapy within 72h prior to enrollment; (7) Participation in other clinical trials within three months; (8) Pregnant or breastfeeding women; (9) Other conditions deemed by the investigator to be unsuitable for enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microbial clearance; | — |
Countries
China
Contacts
Public ContactLong Yun
Peking Union Medical Collage Hospital
Outcome results
None listed