postoperative cognitive dysfunction
Conditions
Interventions
Sufentanil group:Induction of anesthesia:
Sufentanil group: intravenous injection of propofol 1-1.5 mg/kg, sufentanil 0.3ug/kg, when the patient lost consciousness, cisatracurium 0.2 mg/kg, until a sa
The Oxalidine group:Induction of anesthesia:
The patients in the oxalidine group received intravenous injection of propofol 1-1.5 mg/kg and oxalidine 60 ug/kg, and cisatracurium 0.2 mg/kg was given wh
Sponsors
Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) undergoing elective lower limb long bone surgery (the operation time was 3-4 hours); (2) age =65 years old; (3) ASA?/?, MMSE score =23; (4) those who voluntarily participated in the study and signed the informed consent form
Exclusion criteria
Exclusion criteria: (1) known to be allergic to the components of the investigational drug; (2) inability to cooperate, such as mental disorders or anticipated difficulties with neuropsychological assessment, communication difficulties related to pronunciation or dialect. (3) those with a history of alcohol or drug abuse; (4) participants who were enrolled in or had enrolled in another clinical trial within 12 weeks before the trial; (5) Other patients who, in the judgment of the investigator, would not be eligible to participate in the trial, such as acute or chronic infectious diseases, secondary surgery, ASA score greater than grade III, illiteration, stroke or transient ischemic attack within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive impairment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The use of analgesic drugs in patients;Patient's pain level;The mean arterial pressure of the patients during the procedure;Adverse reactions within 24 hours after operation were recorded;Length OF STAY;Continuous pulse oxygen saturation was measured 24 hours after surgery;The first postoperative defecation time;The first time of ground movement; | — |
Countries
China
Contacts
Public ContactPeimin Lin
Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University
Outcome results
None listed