Muscle atrophy in critically ill patients on mechanical ventilation
Conditions
Interventions
SC:According to the current nutritional guidelines, 25kcal/kg/d is recommended as the calorie target, while the protein target is 1.2g/kg/d.
IC:The calorie target is based on the actual resting energy expenditure detected by an indirect calorimetry analyzer, and the protein target is 1.2g/kg/d
Sponsors
Department of Geriatric ICU,the First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age = 18 years old; 2) Respiratory failure caused by various reasons requires tracheal intubation and mechanical ventilation for at least 7 days, with FiO2 = 60%; 3) NRS 2002 = 3 points upon admission to the ICU, requiring nutritional support and treatment; 4) The condition is reversible.
Exclusion criteria
Exclusion criteria: 1) Patients with neuromuscular diseases, hyperthyroidism, and tumors; 2) Existence of cervical spinal cord injury; 3) Severe chest deformity combined without surgical repair, resulting in respiratory function limitation; 4) The respiratory state is unstable and requires frequent adjustment of ventilator parameters; 5) Combined moderate to severe liver dysfunction; 6) Use of glucocorticoids or continuous use of neuromuscular blockers during mechanical ventilation maintenance; 7) Pregnancy; 8) The clinical doctor in charge of treatment believes that this intervention is not in the best interest of the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quadriceps Muscle Layer Thickness;Diaphragm Thickness;Diaphragm Thickening Fraction;Electrical Activity of Diaphragm;Neuro-mechanical efficiency;Neuro-ventilatory efficiency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prealbumin;Transferrin;Urine Urea;Urine Protein;Nitrogen Output;the Successful Rates of Weaning;the Mortality rates in ICU;the Duration of Mechanical Ventilation;the Length of ICU stay; | — |
Countries
China
Contacts
Public ContactZhang Qian
Department of Geriatric ICU,the First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed