depression
Conditions
Interventions
esketamine group :the esketamine group will receive 0.25 mg/kg of esketamine, diluted in 40 mL of saline and infused at a rate of 60 mL per hour over 40 minutes.
Placebo group:the placebo group will receive 40ml saline,infused at a rate of 60 mL per hour over 40 minutes.
Sponsors
Jiangsu Province People's Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women scheduled for elective unilateral breast cancer surgery; 2. Age = 18 years; 3. BDI-13 score = 5; 4. American Society of Anesthesiologists (ASA) grade I to III; 5. Ability to listen, speak, read, write, and communicate.
Exclusion criteria
Exclusion criteria: Contraindications or allergies to esketamine or other medications; Poorly controlled hypertension; Severe cardiac, hepatic, or renal dysfunction; Cerebrovascular diseases; History of psychiatric disorders; Long-term use of psychiatric medications, sedatives, analgesics, or antidepressants before surgery, sedatives, analgesics, or antidepressants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe depression on the first day postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Response and remission rates on postoperative days 1, 7, and 14;Incidence of intraoperative hypotension and hypertension;NRS scores at 24 hours postoperatively;15-item Recovery Quality Scale score;Nausea ;vomiting;Other adverse reactions; | — |
Countries
China
Contacts
Public ContactChun Yang
Jiangsu Province People's Hospital
Outcome results
None listed