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High-flow nasal cannula therapy for reducing the incidence of perioperative hypoxemia in elderly patients undergoing transurethral resection of the prostate at high altitude: a randomized controlled trial

High-flow nasal cannula therapy for perioperative use in elderly patients at high altitude (3650m)

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400090871
Enrollment
Unknown
Registered
2024-10-14
Start date
2024-10-15
Completion date
Unknown
Last updated
2024-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative hypoxemia

Interventions

High-flow nasal cannula (HFNC) group:Patients in the HFNC group received oxygen (set temperature at 37°C, oxygen concentration at 100%, oxygen flow rate at 20 L/min before anesthesia, and increased to
Panmure, Auckland, New Zealand).
Nasal cannula (NC) group:Patients in the NC group also received oxygen via an OptiFlow THRIVE device (set temperature to room temperature, oxygen concentration at 100%, oxygen flow rate at 6 L/min bef

Sponsors

Tibet Autonomous Region People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients with preoperative diagnosis of benign prostatic hyperplasia who intend to undergo TURP surgery; 2. Patients aged = 60 years, ASA grade I-?; 3. Patients with clear consciousness and agree to participate in this study; 4. Patients living in high altitude areas for more than 3 months.

Exclusion criteria

Exclusion criteria: 1. Spinal deformity makes it impossible to perform subarachnoid block; 2. Patients with poor compliance; 3. Patients with systemic or vital organ infection, impaired function of vital organs, such as severe cardiac, pulmonary, hepatic and kidney dysfunction; 4. Patients with mental and cognitive disorders who are unable to conduct research; 5. Nosebleeds and epistaxis; 6. History of COPD or airway obstruction, difficult airway, and recent history of respiratory infection; 7. Failure to strictly fast and have a full stomach before surgery, acute respiratory infection, and major complications during and after surgery.

Design outcomes

Primary

MeasureTime frame
The incidence of hypoxemia during anesthesia (from the start of anesthesia to the patient leaving the PACU);

Secondary

MeasureTime frame
The incidence, number of episodes, and duration of severe hypoxemia, hypotension, hypertension, bradycardia, and tachycardia during anesthesia;Type, frequency, and dosage of medications used for adverse events during anesthesia;Basic vital signs at different time points during anesthesia;Preoperative, intraoperative, and postoperative blood gas analysis results;PACU-related outcomes (RASS score upon admission, awake time, and length of stay);Intraoperative HFNC-related adverse events;Patient comfort score for intraoperative oxygen therapy;Postoperative QoR-15 score;

Countries

China

Contacts

Public ContactDunzhu Zhaxi

Tibet Autonomous Region People's Hospital

980453031@qq.com+86 180 0898 2974

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026