prediabetes
Conditions
Interventions
9-hour eating window:9-hour (8:00-17:00) time-restricted eating pattern
12-hour eating window:12-hour (8:00-20:00) time-restricted eating pattern.
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years; 2. Overweight: BMI = 24 kg/m²; 3. Impaired fasting glucose: fasting blood glucose level of 6.1-6.9 mmol/L (110-125 mg/dL); or impaired glucose tolerance: 2-hour blood glucose level of 7.8-11.0 mmol/L (140-200 mg/dL) during an oral glucose tolerance test; 4. Over the past year, a probability of 90% or higher that the interval between breakfast and dinner was at least 8.5 hours.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with diabetes or currently taking diabetes medication; 2. Secondary blood glucose abnormalities, such as those requiring hormone therapy for thyroid disease, rheumatic disease, or tumors; 3. Suffering from severe cardiovascular, renal, cardiac, hepatic, pulmonary, or neurological diseases; 4. Currently taking any medication that may affect sleep, circadian rhythm, or metabolism; 5. Regular alcohol consumption (more than twice daily); 6. Engaging in any strenuous physical activity; 7. Currently working night shifts at least one day per week or having irregular sleep/eating schedules.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean amplitude of glycemic excursion;time in range;coefficient of variation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose;Glycated serum protein;Fasting insulin;Blood lipids;Body composition test;sleep pattern;mRNA expression in peripheral nuclear cells;Intestinal flora; | — |
Countries
China
Contacts
Public ContactHUANG, Bixia
Peking University Shenzhen Hospital
Outcome results
None listed