Postoperative delirium
Conditions
Interventions
Esketamine group:In the study, the loading dose (0.25mg/kg) was given intravenously after induction and before operation, and the maintenance dose was given continuously at the rate of (0.125mg/kg/h)
saline control group:the control group was given in equal proportion
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.18-65 years old 2.TBSA>30% or ?>10% 3.ASA ?-? level 4. Patients undergoing burn scab grafting under general anesthesia 5. Voluntarily sign informed consen
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative cognitive impairment 2. Preoperative MMSE score was low (MMSE200/110mmHg), or extremely unstable hemodynamics) 6. Patients taking antipsychotic drugs 7. Patients expected to be admitted to the ICU 8.BMI>30kg/m2 9. People with communication disabilities (inability to speak, language difficulty, severe visual or hearing impairment) 10. The expected operation time is less than 1h or longer than 4h 11. Alcohol or drug dependence (at least 3 months before the onset of the disease, drinking more than 100ml of alcohol at least 40 degrees per day; Can not get rid of the desire to use alcohol or drugs, the will to take this substance significantly increased)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POD at 5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of POD at 2 hours after surgery;The severity of POD at 2 hours after surgery and 1-5 days after surger;The pain score at 2 hours and 1-5 days after surgery;The sleep quality at 1-5 days after surgery;Mental state 2 hours after surgery;Occurrence of adverse reactions; | — |
Countries
China
Contacts
Public ContactQianzi Yang
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed