endoscopic retrograde cholangiopancreatography
Conditions
Interventions
R1 group (Remazolam 0.15mg/kg group):Anesthesia induction: Slowly intravenous injection of afentanil 5ug/kg, 30s later, slowly intravenous injection of remazolam 0.15mg/kg
Anesthesia maintenance: Rema
R2 group (Remazolam 0.20mg/kg group):Anesthesia induction: Slowly intravenous injection of afentanil 5ug/kg, 30s later, slowly intravenous injection of remazolam 0.20mg/kg
Anesthesia maintenance: Rema
R3 group (Remazolam 0.25mg/kg group):Anesthesia induction: Slowly intravenous injection of afentanil 5ug/kg, 30s later, slowly intravenous injection of remazolam 0.25mg/kg
Anesthesia maintenance: Rema
Sponsors
Chinese People's Liberation Army Northern Theater Command General Hospital
Eligibility
Sex/Gender
All
Age
75 Years to No maximum
Inclusion criteria
Inclusion criteria: a. Age > 75 years old for ERCP surgery; b.ASA Grade I-III; c. Body mass index (BMI) 18-30 kg/m2; d. The anesthesia method was MAC anesthesia; e. Willing to sign informed consent and strictly follow the clinical study protocol.
Exclusion criteria
Exclusion criteria: a. Circulatory diseases (heart failure, angina pectoris, myocardial infarction, arrhythmia); b. uncontrolled hypertension (systolic =160 mmHg or diastolic =100 mmHg) or hypotension (systolic =90 mmHg or diastolic =60 mmHg); (c) Respiratory diseases (acute respiratory infections, asthma attacks, bronchitis, chronic obstructive pulmonary disease); A D.Allampati score of 3 or 4; e. Liver insufficiency: Child-Pugh grade C or above; f. Renal insufficiency: glomerular filtration rate 2.5 mg/dL; g. Anemia or thrombocytopenia (hemoglobin < 90 g/L, platelet count <80×109 /L); h. Modified Allen test negative; i. Those who are allergic to experimental drugs drink alcohol or use psychotropic drugs or painkillers for a long time; j. Patients with previous history of anesthesia and sedation accidents and contraindications; Participants in clinical trials of other drugs within the last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood oxygen saturation;bispectral index;Dosage of norepinephrine;Bradycardia (HR 1min);hiccup;Injection pain;Time of loss of consciousness (from the first infusion of remazolam to MOAA/S score =1 and BIS<60);Additional sedation cases; | — |
Countries
CHNIA
Contacts
Public ContactDandan SONG
Chinese People's Liberation Army Northern Theater Command General Hospital
Outcome results
None listed