Efficacy of repetitive transcranial magnetic stimulation on social functioning and brain network connectivity in autism spectrum disorders: a randomized controlled clinical trial

Efficacy of repetitive transcranial magnetic stimulation in autism spectrum disorders: a multicenter randomized controlled clinical trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400090840

Enrollment

Unknown

Registered

2024-10-14

Start date

2024-11-01

Completion date

Unknown

Last updated

2024-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autism spectrum disorders

Interventions

rTMS group:Repetitive transcranial magnetic stimulation

Sham-rTMS group:Sham repetitive transcranial magnetic stimulation

Eligibility

Sex/Gender

All

Age

2 Years to 16 Years

Inclusion criteria

Inclusion criteria: (1) Age is between 2 and 16 years. (2) Meets the diagnostic criteria for ASD in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), as well as the diagnostic criteria for the Autism Diagnostic Observation Scale (ADOS), and the Critical Autism Rating Scale (CARS). (3) No behavioral treatment in the last 6 months. Those who have received medication are required to maintain a consistent medication regimen for at least one month prior to study enrollment and throughout the trial. (4) No absolute and relative contraindications to repeat transcranial magnetic stimulation (including: the presence of cochlear or intracranial implants, high cranial pressure, intracranial infections, acute stages of bleeding disorders, history or family history of epilepsy, and comorbidities with other acute and unstable medical conditions). (5) No previous history of traumatic brain injury or surgery.

Exclusion criteria

Exclusion criteria: (1) Comorbidity with other neurological or psychiatric disorders, inherited metabolic disorders. (2) Severe hearing or vision impairment. (3) Inability to cooperate with the examination or evaluation due to, for example, severe cognitive impairment. (4) History of seizures, presence of metal in the skull, history of severe head injury, and implanted medical devices (e.g., pacemakers).

Design outcomes

Primary

Measure	Time frame
Social functioning;	—

Secondary

Measure	Time frame
Multimodal brain imaging;Severity of autism;Intelligence ;Repetitive stereotyped behavior;	—

Countries

China

Contacts

Public ContactNan Chen

Xinhua Hospital Afiliated to Shanghai Jiaotong University School Of Medicine

chennan@xinhuamed.com.cn+86 21 2507 8999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026