HIV
Conditions
Interventions
Intestinal bacteria transplantation group :Intestinal bacteria transplantation
blank control group:Blank treatment
probiotics:probiotics capsule
Sponsors
The Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: Age =18 years old, male or female 2: Line with the People's Republic of China health industry standard (WS293-2008) - "AIDS and HIV infection diagnostic criteria", confirmed as HIV-1 infection 3: After 2 years of ART treatment, ART regimen is not limited, HIV viral load <50 copies /ml, CD4+T cell count < 350 /uL for 2 consecutive times, defined as poor immune reconstitution
Exclusion criteria
Exclusion criteria: 1: Have participated in HIV vaccine clinical trials or other drug trials within the last three months 2: In the past 1 month, there is evidence of fever, acute infection or history of antibiotic use; 3: Evidence of drug addiction (including excessive alcohol consumption) in the year prior to joining the trial 4: A history of serious mental illness, especially depression 5: Pregnant women or breastfeeding women 6: Intestinal obstruction, intestinal perforation or gastrointestinal bleeding 7: Important organ failure 8: Have a history of severe epilepsy or are currently receiving sedatives 9: Evidence of immune-mediated disease, or other malignant disease, or other conditions of the patient that the investigator deems unsuitable for participation in the study 10: The investigator judged that the patient was unable to complete the scheduled follow-up (e.g., weak health, poor compliance, etc.) 11: Inability or unwillingness to provide informed consent or comply with trial requirements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4 lymphocyte count; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora changes; | — |
Countries
China
Contacts
Public ContactJinyu Xia
The Fifth Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed