Pain after laparoscopic abdominal surgery
Conditions
Interventions
Experimental group:Oliceridine multimodal analgesia
Control group:Routine multimodal analgesia
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 18 years old =65 years old; Patients undergoing elective laparoscopic abdominal surgery under general anesthesia; ASA grade I ~ III; BMI: 18.5 ~ 28.0 kg/^m2; Obtain informed consent from patients;
Exclusion criteria
Exclusion criteria: History of surgery under general anesthesia within one month before surgery; Serious systemic diseases such as severe hypertension (crisis), severe diabetes (ketosis, acidosis), coronary heart disease, COPD, asthma, respiratory failure,OSASH ,severe arrhythmia (ECG indicating correction of QT interval, male > 450 ms or female > 470 milliseconds, atrial fibrillation, grade II and above atrioventricular block, sick sinus syndrome, etc.), severe heart valve disease, heart failure, kidney failure, stroke and myocardial infarction within 6 months, Alzheimer's disease, Parkinson's disease, mental illness, myasthenia gravis, etc. Patients with acute or chronic pain (pain from cancer treated with chemotherapy or biologics), dependence on alcohol or opioids, use of psychotropic drugs, allergies to the drugs used in this trial; Hypersensitivity to opioids; Abnormal coagulation function; METs< 4 patients; Patients who refused or were unable to participate in the study; Patients enrolled in other studies within 30 days. Patients who must be converted to open surgery, use drugs not planned for initial anesthesia (inhaled anesthetics, other analgesics, etc.), and develop special complications during surgery (stroke, acute coronary syndrome, circulatory instability due to arrhythmia, liver damage, etc.);Pregnant or lactating women, or who plan to become pregnant .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;Restore bowel exhaust and water intake time;Length of stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total intraoperative and postoperative opioid use;Number of NSAIDS drug remediation and total remediation dosage;PCIA first Time to compression and total number of PCA compressions Type: Secondary indicator :;Postoperative recovery time of extubation;Postoperative opioid adverse events;Perioperative Hemodynamic Parameters and IoC Awareness Injury Index;Results of blood gas analysis and ventilation monitoring at established time points;The scores of QoR-15 and TNF-a, CRP, LPS and PGE2 in blood were determined at a given time point after surgery; | — |
Countries
China
Contacts
Public ContactJiang Wang
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed