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A single low-dose of epidural esketamine provides sustained improvement in morphine analgesia post caesarean delivery : A Randomized Controlled Trial

Evaluation of the effect of morphine combined with esketamine for epidural analgesia after cesarean section

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400090810
Enrollment
Unknown
Registered
2024-10-14
Start date
2024-10-15
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain after cesarean section

Interventions

morphine group:1.5mg of morphine was injected through an epidural catheter
Morphine + esketamine group:1.5mg morphine +0.25mg/kg esketamine was injected through an epidural catheter

Sponsors

Women's Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: The women who delivered elective cesarean section under combined lumbar and epidural anesthesia,20-35 years old, single pregnancy, full term (=37 weeks of age), ASA grade I-II, and needed postoperative epidural analgesia, operation time was 30-60min

Exclusion criteria

Exclusion criteria: Women with severe internal, surgical or obstetric complications (including spinal deformities, hypertension, placental abruption, gestational cholestasis, asthma, heart disease, blood clotting disorders); allergic to the drugs used in this study; with serious mental illness who cannot follow medical advice; chronic pain syndrome, defined as pain lasting more than 3 months.

Design outcomes

Primary

MeasureTime frame
Total ropivacaine requirement in 48 hours after surgery;

Secondary

MeasureTime frame
VAS scores ;the time PCEA supplemental analgesics were first required after surgery;Numbers of PCA compressions in 48 hours after surgery;

Countries

China

Contacts

Public ContactXinzhong Chen

Women’s Hospital, Zhejiang University School of Medicine

chenxinz@zju.edu.cn+86 135 7573 8058

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026