Effect of esketamine combined with hydromorphone on nausea and vomiting after radical resection of colorectal cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400090806

Enrollment

Unknown

Registered

2024-10-14

Start date

2024-11-01

Completion date

Unknown

Last updated

2024-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

control group:Postoperative analgesic intravenous pump: hydromorphone (0.1 mg/kg hydromorphone + 10mg troisetron, diluted to 100 mL with 0.9% normal saline)

intervention group:Intravenous pump for postoperative analgesia: intravenous pump mixed with hydromorphone and esketamine (0.1mg /kg hydromorphone +1mg/kg esketamine + troisetron 10mg, diluted to 100

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Age 18-75 years old, gender is not limited; (2) Body mass index (BMI) 18-30 kg/m2; (3) American Society of Anesthesiologists (ASA) : Level II-III; (4) Patients who plan to undergo elective laparoscopic radical resection of colorectal cancer under general anesthesia; (5) Receiving patient-controlled intravenous analgesia (PCIA) after surgery; (6) Voluntarily participate in the study and sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) Allergy to the drugs used in this study; (2) A history of chronic pain or opioid abuse before surgery; (3) Preoperative history of mental illness or use of antipsychotic drugs; (4) severe heart, brain, liver and kidney diseases (heart failure, myocardial infarction, cerebral infarction, Child-Pugh grade C and renal replacement therapy); (5) untreated or uncontrolled high blood pressure; (6)History of glaucoma, elevated intracranial pressure, hyperthyroidism, or alcoholism.

Design outcomes

Primary

Measure	Time frame
Incidence of PONV within 48 hours after surgery;	—

Secondary

Measure	Time frame
Postoperative PONV severity score;NRS pain scores at rest and cough within 48 hours after surgery;PACU duration of stay;the satisfaction of patients;Postoperative hospital stay;Number of effective PCIA compressions within 48 hours after surgery;Adverse event within 48 hours after surgery;	—

Countries

China

Contacts

Public ContactWang Ye

Department of Anesthesiology, Peking University Shougang Hospital

minami01@163.com+86 138 1038 6807

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026