Hypotension after induction of anesthesia
Conditions
Interventions
Propofol group:Propofol 1.5 mg/kg/min
Remimazolam group:Remimazolam 0.2 mg/kg/min
Etomidate group:Etomidate 0.3 mg/kg/min
Sponsors
Department of Anesthesiology, First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
80 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged =80 years, ASA physical status I-III; patients undergoing elective non-cardiac surgery under endotracheal intubation after intravenous anesthesia induction; patients who clearly understand the trial process and voluntarily participate in this study with signed informed consent.
Exclusion criteria
Exclusion criteria: BMI = 35 kg/m^2; allergy to the drugs in the study; severe cardiopulmonary disease, severe liver disease, kidney disease requiring dialysis; systolic blood pressure = 200 mmHg and/or diastolic blood pressure = 120 mmHg before anesthesia; use of antipsychotics, antidepressants, tranquilizers or other sedatives; sleep apnea or expected difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post-induction hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction time of anesthesia;tracheal intubation time;Incidence of > 30% decrease in mean arterial pressure;Dose of vasopressors;Bradycardia (HR < 45 bpm);Injection pain;Myoclonus;Postoperative delirium;Cardiac, cerebral and renal complications during hospitalization ; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed