postoperative delirium
Conditions
Interventions
Low Opioid Anesthesia:Anesthesia was maintained with remifentanil (0.1 µg/kg/min) by target-controlled pump combined with dexmedetomidine (0.3 µg/kg) by intravenous infusion. The level of analgesia an
Control :Anesthesia was induced and maintained with remifentanil (0.25 µg/kg/min) by target-controlled pump. Patient-controlled intravenous analgesia (PCIA) with sufentanil was used after operation
Sponsors
Department of Anesthesiology, Nanjing Women and Children’s Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) ASA I-II; (2) age =60 years old; (3) body mass index =35 kg/m2; (4) Elective pelvic floor surgery
Exclusion criteria
Exclusion criteria: (1) previous psychiatric diseases (such as Parkinson's disease, depression, anxiety, etc.); (2) contraindications to general anesthesia or patients refusing general anesthesia; (3) patients with known ingredients of the study drug or allergy to other drugs used in the study; (4) use of opioids and other sedative and analgesic drugs within one week; (5) patients with a history of drug abuse; (6) patients with severe heart, lung, liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| The intraoperative IoC1 and IoC2 indexes of the two groups;Total intraoperative and postoperative opioid consumption; | — |
Countries
China
Contacts
Public ContactHong-mei Yuan
Nanjing Women and Children’s Healthcare Hospital
Outcome results
None listed