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Antidepressant Effects of Temporal Interference Electrical Stimulation Targeting vmPFC Theta/Alpha Rhythms

Research on the Effects and Mechanisms of Non-invasive Interferential Stimulation in Regulating Emotion and Cognition

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400090777
Enrollment
Unknown
Registered
2024-10-12
Start date
2024-10-12
Completion date
Unknown
Last updated
2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

individuals with subthreshold depression

Interventions

Alpha group:A 3-day intervention targeting vmPFC, with 20 minutes per day. The stimulation frequencies are 2000 Hz and 2010 Hz, with current intensities of 0.85 mA and 1.15 mA per channel, respectivel
Theta group:A 3-day intervention targeting vmPFC, with 20 minutes per day. The stimulation frequencies are 2000 Hz and 2005 Hz, with current intensities of 0.85 mA and 1.15 mA per channel, respectivel
Sham group:A 3-day intervention targeting vmPFC, with 20 minutes per day. The stimulation frequencies are 2000 Hz and 2000 Hz, with current intensities of 0.85 mA and 1.15 mA, respectively. TI stimula

Sponsors

School of Psychology, Shenzhen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1)Individuals with subthreshold depression, with a CES-D score > 16 and a BDI score = 10. 2)Aged between 18 and 65 years, regardless of gender, all participants must be right-handed. 3)No history of epilepsy, neurological diseases, or other medical conditions. 4)Not currently undergoing any psychiatric or other treatments. 5)Have not participated in any other neuromodulation experiments in the past seven days. 6)Participants must agree to participate in this study and sign an informed consent form.

Exclusion criteria

Exclusion criteria: individuals with a history of mental disorders, brain injury, neurological disorders or substance abuse

Design outcomes

Primary

MeasureTime frame
Depressive symptom;Behavioral outcomes in the reinforcement learning task;Behavioral outcomes in the reinforcement learning task;

Countries

China

Contacts

Public ContactYiheng Tu

Institute of Psychology, Chinese Academy of Sciences

tuyh@psych.ac.cn+86 10 6485 3798

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026